CNS – Diffuse Large B-cell Lymphoma
Profile
- 21-year-old male diagnosed withB-cell acute lymphoblastic leukemia as a child
- Age 20 MRI: brain mass in left cerebellum; biopsy consistent with primary CNS DLBCL
- Status post first line therapy
Work Up
- Hereditary cancer panel: negative
- CSF cytology: negative/indeterminate
- Summit genomic profiling for post-treatment monitoring in CSF
Summit™ Report
- Detected variant where other testing was negative
- TP53 detected in CSF is evidence of disease
- Provides diagnostic implications for lymphocytic neoplasms per WHO
