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Case #4 | Less Invasive Approach to Detect Brain Metastasis¹

Abnormal Brain Scan

Profile

  • 80-year-old female
  • Prior history of clear cell renal cell cancer
  • Abdominal metastasis
  • Hyperintense mass in ventricles

Work Up

  • Suspected Dx: secondary CNS cancer
  • Lesion on MRI suggests brain metastasis
  • Summit molecular profile in CSF
  • Differential diagnosis included choroid plexus carcinoma not amenable to biopsy

Summit™ Report

  • Summit test detects TP53 Y220C variant in CSF
  • TP53 mutation informs diagnosis of choroid plexus carcinoma 

This is an image of an actual Belay Diagnostics Summit™ test report illustrating specifics of Case #4 | Less Invasive Approach to Detect Brain Metastasis, Abnormal Brain Scan
References:

1. https://doi.org/10.1093/noajnl/vdaf146