Belay Summit™
Tumor-derived DNA in CSF
Next-generation sequencing of tDNA in CSF
Summit detects gene level variants and chromosome arm level alterations from tumor-derived DNA (tDNA) in CSF to help inform the diagnosis and management of primary and secondary CNS malignancies.
Why choose Belay Summit?
- Molecular characterization can markedly enhance diagnostic accuracy, tumor classification, predictive prognosis, and treatment selection1
- CNS metastasis can have different molecular profiles than primary tumors with distinct targetable mutations, due to clonal evolution during neoplasm migration2
- Genomic abnormalities associated with CNS cancers can be detected prior to performing resections or biopsies that impose clinical risk
1. Park SH, Won J, Kim SI, Lee Y, Park CK, Kim SK, Choi SH. Molecular Testing of Brain Tumor. J Pathol Transl Med. 2017 May;51(3):205-223. doi: 10.4132/jptm.2017.03.08. Epub
2017 May 12. PMID: 28535583; PMCID: PMC5445205.
2. Shen E, Van Swearingen AED, Price MJ, Bulsara K, Verhaak RGW, Baëta C, Painter BD, Reitman ZJ, Salama AKS, Clarke JM, Anders CK, Fecci PE, Goodwin CR, Walsh KM. A Need for More Molecular Profiling in Brain Metastases. Front Oncol. 2022 Jan 25;11:785064. doi: 10.3389/fonc.2021.785064. PMID: 35145903; PMCID: PMC8821807.
3. Nie Q, Schilter KF, Hernandez KM, Adams JN, Jagadish R, Acevedo A, Larson A, Domagala BA, Vo SA, Khurana S, Mitchell K, Ellis D, Muhammedov B, Wang Y, Douville C, Coe B, Bettegowda C, Reddi HV. Analytical Validation and Clinical Sensitivity of the Belay Summit Assay for the Detection of DNA Variants in Cerebrospinal Fluid of Primary and Metastatic Central Nervous System Cancer. J Mol Diagn. 2025 Jul;27(7):615-629. doi: 10.1016/j.jmoldx.2025.03.010. Epub 2025 Apr 23. PMID: 40280408; PMCID: PMC12264565.