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Case #3 | Inform Localized vs. Systemic Disease
Vitreoretinal Lymphoma
Profile
65-year-old female
Provisional Dx: Vitreoretinal lymphoma
Multiple prior cancers s/p systemic therapy
Extent of CNS involvement?
Work Up
Vitrectomy: atypical lymphoid cells, MYD88 L265P
Repeat imaging shows no intracranial involvement
CSF cytology: negative/indeterminate
Summit molecular profile in CSF
Summit™ Report
MYD88 L265P detected in CSF confirms broader CNS involvement
Discussed at tertiary center tumor board
Treated with systemic low dose MTX instead of local intraocular injection
Monitor VAF of MYD88 with serial Summit testing
Over time, MYD88 not detected (negative). Clinician confirms response to therapy.
