Abnormal Brain Scan
Profile
- 80-year-old female
- Prior history of clear cell renal cell cancer
- Abdominal metastasis
- Hyperintense mass in ventricles
Work Up
- Suspected Dx: secondary CNS cancer
- Lesion on MRI suggests brain metastasis
- Summit molecular profile in CSF
- Differential diagnosis included choroid plexus carcinoma not amenable to biopsy
Summit™ Report
- Summit test detects TP53 Y220C variant in CSF
- TP53 mutation informs diagnosis of choroid plexus carcinoma
References:
1. https://doi.org/10.1093/noajnl/vdaf146
