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Case #5 | Inform Diagnosis of LMD/Therapeutic Intervention

Metastatic Lung Adenocarcinoma

Profile

  • 76-year-old male
  • Prior Dx: brain metastatic lung cancer
  • Currently on osimertinib
  • Suspect LMD
  • Prior tissue biopsy: EGFR exon 19 deletion/MET amplification/PD-L1+
  • Prior plasma liquid biopsy: EGFR exon 19 deletion

Work Up

  • Summit molecular profile in CSF

Summit™ Report

  • Detects EGFR E746_P753 delinsVS and TP53 E258* variants
  • Reports six targeted therapeutic options and averts high-risk biopsy
  • Provides diagnostic and prognostic implications per WHO